Stefan L Marklund Selected Research

Superoxide Dismutase-1

1/2022	Infantile SOD1 deficiency syndrome caused by a homozygous SOD1 variant with absence of enzyme activity.
1/2022	Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS.
1/2021	Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice.
1/2019	The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension.
1/2019	[Prion-like Properties of Misfolded Cu/Zn-superoxide Dismutase in Amyotrophic Lateral Sclerosis: Update and Perspectives].
12/2018	Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis.
6/2017	Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations.
1/2016	Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis-like disease.
1/2016	Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients.
4/2015	Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping.

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Stefan L Marklund Research Topics

Disease

39	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 08/2003
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 01/2012
4	Myocardial Infarction 01/2015 - 05/2009
4	Cataract (Cataracts) 11/2012 - 12/2005
3	Stroke (Strokes) 01/2010 - 01/2007
3	Inflammation (Inflammations) 07/2007 - 05/2002
2	Disease Progression 06/2013 - 03/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 08/2010 - 01/2010
2	Ischemic Stroke 01/2010 - 01/2007
2	Hyperoxia 05/2009 - 05/2002
2	Hypertension (High Blood Pressure) 03/2007 - 10/2003
1	Muscle Hypotonia (Hypotonia) 01/2022
1	Parkinson Disease (Parkinson's Disease) 04/2016
1	Type 2 Diabetes Mellitus (MODY) 01/2015
1	Frontotemporal Dementia (Semantic Dementia) 10/2012
1	Colorectal Neoplasms (Colorectal Cancer) 03/2012
1	Carcinogenesis 03/2012
1	Hemorrhage 03/2012
1	Proteostasis Deficiencies 01/2012
1	Diabetes Mellitus 06/2009
1	Keratoconus 07/2007
1	Corneal Injuries 07/2007
1	Albuminuria 01/2007
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2007
1	Hemorrhagic Stroke 01/2007
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2007
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2007
1	Motor Neuron Disease (Primary Lateral Sclerosis) 12/2006
1	Atherosclerosis 03/2005
1	Hemolysis 11/2004
1	Renovascular Hypertension (Goldblatt Syndrome) 10/2003
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2003
1	Ulcerative Colitis 09/2003
1	Crohn Disease (Crohn's Disease) 09/2003
1	Hypersensitivity (Allergy) 05/2002

Drug/Important Bio-Agent (IBA)

27	Superoxide Dismutase-1IBA 01/2022 - 01/2004
18	Superoxide DismutaseIBA 12/2018 - 05/2002
13	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2002
7	Superoxides (Superoxide)IBA 03/2013 - 12/2005
7	AntioxidantsIBA 11/2012 - 09/2003
7	EnzymesIBA 11/2012 - 05/2002
5	CopperIBA 06/2013 - 12/2005
4	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2012 - 01/2007
4	ZincIBA 11/2012 - 12/2005
3	PrionsIBA 01/2020 - 01/2016
3	IronIBA 03/2012 - 01/2007
3	Biomarkers (Surrogate Marker)IBA 03/2012 - 08/2009
3	BilirubinIBA 08/2010 - 11/2004
3	Glucose (Dextrose)FDA LinkGeneric 06/2009 - 12/2005
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 04/2007 - 05/2002
2	Protein AggregatesIBA 08/2015 - 01/2012
2	Oxygen (Dioxygen)IBA 11/2012 - 09/2003
2	Transferrin (beta 2 Transferrin)IBA 07/2011 - 01/2007
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2009 - 04/2007
2	CytokinesIBA 07/2007 - 05/2002
1	Complementary DNA (cDNA)IBA 01/2022
1	Pyrimethamine (Daraprim)FDA Link 06/2017
1	IsoprostanesIBA 01/2015
1	Advanced Oxidation Protein Products (AOPP)IBA 01/2015
1	Chelating AgentsIBA 06/2013
1	tetrathiomolybdate (ammonium tetrathiomolybdate)IBA 06/2013
1	Glutathione (Reduced Glutathione)IBA 06/2009
1	Streptozocin (Streptozotocin)FDA Link 06/2009
1	ProteomeIBA 06/2009
1	Heparin (Liquaemin)FDA LinkGeneric 05/2009
1	Interleukin-1alpha (Interleukin 1 alpha)IBA 07/2007
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 04/2007
1	1- hydroxy- 2- oxo- 3,3- bis(2- aminoethyl)- 1- triazeneIBA 04/2007
1	Reactive Nitrogen SpeciesIBA 04/2007
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 03/2007
1	Valine (L-Valine)FDA Link 01/2007
1	Ferritins (Ferritin)IBA 01/2007
1	Alanine (L-Alanine)FDA Link 01/2007
1	Antihypertensive Agents (Antihypertensives)IBA 01/2007
1	valylvaline (Val-Val)IBA 01/2007
1	AlbuminsIBA 01/2007
1	oxidized low density lipoproteinIBA 03/2005
1	Hemoglobins (Hemoglobin)IBA 11/2004
1	HaptoglobinsIBA 11/2004
1	Angiotensin IIIBA 10/2003
1	Protein Isoforms (Isoforms)IBA 09/2003
1	ImmunosorbentsIBA 09/2003
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2003
1	ZymosanIBA 05/2002
1	Interleukin-5 (Interleukin 5)IBA 05/2002
1	OvalbuminIBA 05/2002
1	EndotoxinsIBA 05/2002

Therapy/Procedure

3	Lenses 06/2009 - 12/2005
1	Corneal Transplantation (Keratoplasty) 07/2007
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2007
1	Surgical Instruments (Clip) 10/2003